Interaction between high-density lipoproteins and inflammation: Function matters more than concentration!
نویسندگان
چکیده
منابع مشابه
High-density lipoproteins, inflammation and oxidative stress.
Plasma levels of HDL (high-density lipoprotein)-cholesterol are strongly and inversely correlated with atherosclerotic cardiovascular disease. Both clinical and epidemiological studies have reported an inverse and independent association between serum HDL-cholesterol levels and CHD (coronary heart disease) risk. The cardioprotective effects of HDLs have been attributed to several mechanisms, in...
متن کاملEffects of inflammation on high-density lipoproteins.
High-density lipoproteins (HDLs) protect against the development of atherosclerotic coronary heart disease.1 In part, this reflects the ability of HDL to promote the efflux of cholesterol from macrophages in the artery wall2 but given that atherosclerosis is an inflammatory disorder,3 it may also reflect anti-inflammatory properties of HDL.4,5 Conversely, inflammation reduces the concentration ...
متن کاملHigh-density lipoproteins and endothelial function.
Elevated plasma levels of HDL cholesterol or apolipoprotein A-I, the major protein moiety of HDL particles, are protective against coronary artery disease. HDL particles remove cholesterol from peripheral cells and transfer it to the liver for bile acid synthesis. The interaction between lipoproteins is not mediated through simple contact between 2 phospholipid membranes but involves specific p...
متن کاملSerum amyloid A: high-density lipoproteins interaction and cardiovascular risk.
AIMS High-density lipoproteins (HDLs) are considered as anti-atherogenic. Recent experimental findings suggest that their biological properties can be modified in certain clinical conditions by accumulation of serum amyloid A (SAA). The effect of SAA on the association between HDL-cholesterol (HDL-C) and cardiovascular outcome remains unknown. METHODS AND RESULTS We examined the association o...
متن کاملHigh-density lipoproteins inhibit urate crystal-induced inflammation in mice.
OBJECTIVES To investigate the effects and mechanisms of action of high-density lipoproteins (HDL) in monosodium urate (MSU) crystal-induced inflammation -that is, gouty inflammation, in vivo. METHODS Air pouches raised on the backs of mice were injected with MSU crystals or tumour necrosis factor (TNF) in the presence or absence of HDL and/or interleukin (IL)-1 receptor antagonist (IL-1Ra) fo...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Advanced Drug Delivery Reviews
سال: 2020
ISSN: 0169-409X
DOI: 10.1016/j.addr.2020.10.006